The Forensic Crash Unit is investigating a fatal collision on the Bruce Highway north of Gympie.
Police says a Nissan Terrano and Toyota Yaris crashed head-on at Kanigan just after 8.15pm on Thursday night.
A 41-year-old Sunshine Coast woman was declared deceased at the scene.
A 23-year-old Greenbank man was taken to Gympie Hospital with serious injuries.
Anyone with information about the incident is urged to contact police.